The draw for the last eight of the Copa del Rey was conducted on Friday.
Defending champions, Barcelona, will take on bitter rivals Espanyol. Ernesto Valverde’s men are seeking to win the King’s Cup for a record 30th time.
Real Madrid, who trail Barca with 16 points in the league, face Leganes. Zinedine Zidane will be keen to focus on the competition and the UEFA Champions League in his quest for silverware this campaign.
Valencia play Alaves and Atletico Madrid have been drawn against Sevilla.
Full Copa del Rey quarter-final draw:
Leganes vs Real Madrid
Espanyol vs FC Barcelona
Atletico Madrid vs Sevilla
Valencia vs Alaves